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Parkinson’s Disease
Majid Ali, M.D.
Parkinson’s disease is a clinical
syndrome of flat facial affect (diminished
expression), sluggish movements, stooped posture ,
and festinating gait (a "shuffling" walk with
progressively shortened, accelerated steps).
Following are principle entities included in
Parkinsonism:
1. Idiopathic Parkinson's disease
2. Striatonigral degeneration
3. Shy-Dager syndrome (associated
with autonomic dysfunction (oxidative dysautonomia)
with orthostatic hypotension).
4. Progressive supranuclear palsy
5. Drug-induced Parkinsonism,
especially methyl phenyl tetrahydropyridine (MPTP)
produced as a byproduct in illicit production of
meperidine analogues
6. Postencephaltic Parkinsonism
The common pathogenetic mechanism
in all involves injury to nigrostriatal dopaminergic
system. Pathological features include pallor and
depigmentation of substantia nigra and locus
ceruleus. Histologically, there is loss of pigmented
catecholaminergic neurons, gliosis, and presence in
neurons of bright eosinophilic Lewy bodies.
Monoamine oxidase inhibitors are
of limited benefits in the early stages.
Stereotactic implants of fetal mesencephalic tissue
into the striatum show some promise. Fetal cell
injections with implants into the striatum tissue
are also sometimes helpful for variable periods of
time. Aggressive integrative detox, nutrient, and
chelation therapy in early to moderate cases appear
to give the best results.
*
A Brief
History of Discovery of the Autonomic Nervous System
*
The Oxygen
Model Alzheimer's Disease
*
Zapping the Brain
Optogenetics
*
Whose Brain Will Be
Zapped by Who and for What?
*
Anatomy of the
Parasympathetic Nervous System
*Rising
Prevalence of Autism Spectrum
*
Stroke
* Brain
Edema
*
Cerebral Ischemia and Infarction
*
Brain Aneurysms
* Multiple
Sclerosis (MS) and Demyelinating Diseases
*
Parkinson’s
Disease
*
Lou Gehrig
Disease (ALS)
*
Pick's Disease
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