Course on Oxygen  

           Oxygen Models of Diseases

                                      Majid Ali, M.D.

My Oxygen Model of Diseases are extensions of my Oxygen Model of Health and Disease. It is a unifying model that explains all aspects of diverse diseases—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among these compromised and/or blocked functions are: (1) oxygen signaling; (2) oxygen’s ATP energy generation; (3) oxygen’s detergent functions; (4) oxygen’s cellular detox functions; (5) oxygen-regulated cell membrane and matrix functions; (6) oxygen’s cellular repair roles.

The Oxygen Model of Diseases provide a simple model that allows physicians to reduce complexities of diverse clinical syndromes into a workable simplicity.

These models predict that ongoing research will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features of various diseases.

Darwin’s Core Tenet of Natural Selection

The strength of Darwin’s core tenet of natural selection is that in biology so little explains so much. The core strength of The Oxygen Model of Disease, in my view, is that in medicine so little explains so much.

Charles Robert Darwin (1809-1882) published Origin of Species (1869) to propose a spectacular simplicity: all species evolved from a common primordial ancestor, and so are related to each other. During my work for thirty five years in surgery and pathology over thirty years I wondered if there were a similar simplicity about the origin of diseases. I opened my book Oxygen and Aging (2000) with the following words: oxygen is the organizing principle of human biology and governs the aging process. The core tenet of my Oxygen Model of Disease is that the origin of all diseases can be ultimately traced to oxygen-related molecular and cellular injury, and so are related to each other.

Strong claims require strong evidence. To support The Oxygen Model of Disease, I marshaled an enormous body of clinical, microscopic, and experimental evidence in Darwin and Dysox Trilogy (2009), the tenth, eleventh, and twelfth volumes of my textbook entitled The Principles and Practice of Integrative Medicine.

Darwin’s message for us is: no part can be understood without understanding its relationships with the whole. His message to physicians today would have been simple as well: no disease of any organ can be understood or prevented without understanding the relationships of that organ with other organs of the body-holism and integration in structural and functional aspects of the various organ-systems of the body, in simple words.

Major Oxygen Models of Diseases

Oxygen's Three Legged Throne

In the tutorial entitled "Oxygen's Three-legged Throne," I present a unifying model of origin of diseases. Briefly, in this model the trio of toxicities of foods that cause the molecular trio of excess acidity (acidosis), increased free radical activity (oxidosis), and clotting-unclotting dysequilibrium (CUD), which disrupt the oxygen order of the human body. The resulting trio of 3-M states-greased cell membranes, gummed matrix, and gutted mitochondria-is the origin of all diseases.

Cardiologists do not seek solutions to the problems of coronary heart disease in the problems of the bowel. Nor do kidney specialists who simply watch rising creatinine levels until they consider the patient to be ready for dialysis or kidney transplant. Doctors treat insulin toxicity of Type 2 diabetes with drugs that further increase the degrees of insulin toxicity, without considering issues of greased cell membranes, gummed matrix, and gutted mitochondria that cause insulin toxicity. Dermatologists, to my knowledge, never address mold and food allergy, gut fermentation, production of mold toxins, and the leaky gut state - the underlying problems of psoriasis - when they treat the disease with steroids, methotrexate (a chemo drug), or Embrel (a drug that blocks a crucial healing mechanism). Neurologists do not look for solutions to the problems of memory loss in dementia and Alzheimer's disease in the dysfunctions of the liver.

I strongly recommend that readers undertake a study of my free YouTube self-learning ten-part video course in which I present basic information on energy for health and healing. It explains the scientific facts of energy and metabolism in simple words. The important points are illustrated with easy-to-understand examples and analogies. Click below for an outlines and a suggested study schedule:

* Free YouTube Course on Cellular Energy for Health and Healing

Below, I apply The Oxygen Model of Disease to the origin of diseases of the heart, kidneys, skin, and brain to illustrate the enormous explanatory and therapeutic power of the oxygen model to the origin of diseases.

The Heart

A water pump functions well when it pumps clean water. An air pump functions well when it pumps clean air. A blood pump is also expected to function well when it pumps clean blood. The heart is a blood pump. The blood thickens and becomes "dirty" when toxins are absorbed in excess from the bowel and the liver is unable to remove them efficiently (including acids produced in excess by stress states. All elements that either cause excess production of toxins in the blood or inefficient removal by the liver are oxygen-related. I explain these crucial relations in tutorials devoted to cardiovascular disorders. For professional readers, I offer incontrovertible microscopic and biochemical proof of these statements in Darwin and Dysox Trilogy (2009).

The Kidneys

A water filter functions well when it filters clean water. An air filter functions well when it filters clean air. A blood filter is also expected to function well when it filters clean blood. The kidneys are blood filters. They are blocked and injured when thickened and “dirty” blood flows through them. All elements that pollute and thicken blood are oxygen-related. These subjects are presented at length in tutorials devoted to the reversal of kidney failure. For professional readers, I offer incontestable microscopic and biochemical proof of these statements in Darwin and Dysox Trilogy (2009).

Type 2 Diabetes

Type 2 diabetes is an insulin toxicity problem. In my crank-crank-shaft model of insulin resistance, the pancreas produces excess insulin to overcome resistance of the insulin receptor to the hormone. Simply stated, the crank of insulin fails to move (activate) the crank-shaft of insulin receptors embedded in the "hardened" cell membranes—the crank-shaft is rusted, turned, and twisted, so to speak—rendering insulin dysfunctional. In my The Grease and Detergent Model of Disease, the cell membranes, matrix, and mitochondria are covered with "cellular grease": due to insufficient detergent functions of the body. The primary detergent in the body is oxygen. So, in the final analysis, diabetes is an oxygen problem.

The Skin

As roots are to roses, so the bowel to the skin. I have never seen a patient with psoriasis who did not have mold and food allergy, gut fermentation, production of mold toxins, and the leaky gut state. The skin of nearly all my patients with the disorder cleared when these issues—first and foremost, related to oxygen homeostasis—were effectively addressed (see tutorials on the subject for details).

As roots are to roses, so the bowel to the brain. Need I say more about neurologists and their drugs for memory disorders?

A tree analogy is often used to illustrate Darwin’s central idea of the development of species from a common ancestor. In the accompanying figure, I present a “tree of disease origin” to schematically illustrate the core point of The Oxygen Model of Disease and my unifying model of the origin of all diseases.

ORIGIN OF DISEASES
The Oxygen Model of Disease

Seven Levels of Understanding

First, oxygen is the organizing influence of human biology and governs the aging process.
It is also a molecular Dr. Jekyll/Mr. Hyde par excellence, ushering life with one sleight of hand and terminating it with another.

Second, human biology is an enormous web of webs, a vast and intricate network of energetic-molecular pathways. Everything in that web is connected to everything else, and all are related to oxygen.


Third, the webs of human biology form a panoramic kaleidoscope. A singular change within that kaleidoscope causes everything to change.

Fourth, spontaneity of oxidation (loss of energy and decay) in nature-sustained by oxygen above all else-provides the primary metabolic drive for all human life processes. It also assures that no oxygen-utilizing life form lives forever.

Fifth, persistent and progressive oxidosis sets the stage for dysoxygenosis-a state of dysfunctional cellular oxygen metabolism (dysox) resulting from an impaired function of enzymatic pathways involved with oxygen utilization.

Sixth, the spiritual serenity that is essential for long-term good health; and
Seventh, chronic anger and sadness that fan the fires of acidosis (excess acidity), oxidosis (excess oxyradical activity), and dysox.

The Mind-Body-Spirit Trio

The so-called mind-body-spirit trio is an artifact of thinking. I have never seen anyone dissect a human and delineate where the body ends and the mind begins, nor where the mind ends and the spiritual begins. The mind cannot ordain healing on injured tissues. Preoccupation with clever thinking, in reality, is an expression of our inability to sense, feel, and know the wholeness of the human condition. The issues of chronic anger and aspects of spiritual serenity are presented in tutorials devoted to these subjects.

All clinical work by a practitioner of integrative medicine, in my view, should be based on a clear understanding of the above seven oxygen-governed energetic-molecular dynamics of human biology. This is the primary clinical importance of the oxygen model of origin of diseases. Some doctors might protest that evidence of all statements in this tutorial is not established. This does not discourage me since new evidence of Darwin's evolution by natural selection continues to be unearthed even now. I do think the same will hold for evidence of the "oxygen view of disease origin" as well.

For additional reading on the subject, I suggest my book Oxygen and Aging (2000), available at www.aliacademy.org

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Related Links

For additional reading on the subject, I suggest my book Oxygen and Aging (2000).

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http://majidalimd.com/oxygen_and_adrenal_dysfunction.htm

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