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Fermentation
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Good, Bad, and Ugly
Majid Ali, M.D.
Our early primordial ancestors were fermenters.
Throughout human evolution, some of those fermenting
cells thrived in oxygen-poor nitches in the human
body, serving many purposes, including food
digestion. These were “good fermenters.” Our later
human ancestors learned—experientially or
intuitively, it seems—learned ferment foods to
enhance their value. We can call it “good
fermentation.”
Every chronic disease begins with fermentation. This
need not raise any eyebrows. Diseases involve
inflammation with buildup of acids and alcohols.
Fermentation, of course, is conversion of sugars
into alcohols and acids. We can call it “bad
fermentation.”
Then came the age of fermenting human cells—most
notably during the last century—ushered in by the
era of antibiotics, sugar abuse, and industrial
pollutants. The modern epidemics of inflammatory,
immune, and degenerative disorders are rooted in
cellular fermentation. In a broader evolutionary
context, I recognize these epidemics as
evolution-in-reverse. This is “ugly inflammation.”
This article is a part of my series (begun in the
early 1980s) on good fermentation. Citations and
links to my series on bad and ugly fermentation are
included at the end of the article.
Laps and Taps: the Good and Bad Guys of the Bowel
LAPs and TAPs are my terms for lactic acid-producing
and toxic agents-producing microbes in the bowel.
LAPs preserve the normal bowel ecosystem, TAPs
disrupt it.
In my book entitled “The Caanary and Chronic
Fatigue” (1994), I discussed many elements that
increase oxidative stress on energy and
detoxification enzymes. It turns out that almost all
these elements also suppress LAPs and — both
directly by inhibiting LAPs and indirectly by other
mechanisms — promote the growth of TAPs. This
subject is of enormous significance in the normal
aging process as well as in the accelerated aging
process associated with chronic fatigue states.
LAPs confer many important host defenses upon the
bowel discussed later in this section. TAPs are
equally versatile in their functions and produce a
very large number of noxious substances in the
bowel. Among these are ammonia; phenols; tryptophan
metabolites; vaso-constrictive amines such as
histamine, tyramine, agmatine and cadaverine;
certain steroid metabolites; and many toxins — most
notably mycotoxins derived from fungi (yeasts). This
area has received rather limited investigative
attention, and it is almost certain that future
research will uncover a host of as yet undetected
bacterial and fungal toxins and metabolic villains.
Finally, the bowel flora both produce and potentiate
some carcinogenic substances.
Not unexpectedly, LAPs-TAPs dynamics are profoundly
influenced by food choices. American and British
individuals show overgrowth of some TAPs such as
bacteroides and some types of clostridia as compared
with Japanese, Indians and Ugandans (Lancet
1:95-100; 1971). It appears likely that these
differences are due to an abundance of fats and beef
in the former populations' diet.
Dysfunctional Oxygen Signaling
In 1998, I introduced the term dysoxygenosis (dysox,
for short) for this disease-causing “ugly
fermentation.” This age of
respiratory-to-fermentative shift arrived in our
times—most notably during the 20th century—was
ushered in antibiotics, sugar abuse, and industrial
pollutants. The modern epidemics of inflammatory,
immune, and degenerative disorders are rooted in
cellular fermentation. In a broader evolutionary
context, I recognize these epidemics as
evolution-in-reverse. In 1998, I introduced the term
dysoxygenosis (dysox, for short) for this
disease-causing “ugly fermentation. Simply stated,
the dysox state is characterized by degradative
metabolic shift from high-efficiency human
energetics to low-efficiency energetics of yeast and
other fermenting microbes. The full text of my
original published in The Journal of Integrative
Medicine containing numerous photomicrographs and
extensive bibliography is available free of cost at
www.drali.org (Google ORPEC and Ali for quick
search). I devote the 10th, 11th, and 12th volumes
of my textbook entitled “The Principles and Practice
of Integrative Medicine” to an in-depth treatment of
these subjects.
For additional reading on the subject, I suggest my
book Oxygen and Aging (2000), available at
www.aliacademy.org
Course Readings
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Fermentation
Course
k
Good
Fermentation, Good, Bad, and Ugly
k
I
Am Fermenting, My Breath Is My Own
k
Respiratory-to-Fermentative (RTF) Shift in ATP
Production
k
Oxygen's
Three-Legged Throne
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Dysox: Energy and Detox Failure in Cells
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Yeast Syndromes
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The Oxygen Model of Diseases
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Oxygen
Kaleidoscope
k Molecular
Biology of Oxygen Advanced
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The dysox Model of
Aging
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What Does Chlorophyll Reveal About the Origin of
Life on the Planet Earth?
k
Origin of Life,
Origin of Disease
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Oxygen-Driven Energetics: An Intelligent Design
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Oxygen-In-Acids-Out Healing Series
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Dysox: Energy and Detox Failure in Cells
k Free
YouTube Course on Energy Events in Health and
Healing
k
Oxidation
and Oxidosis
k
Oxygen Model of Heart Disease
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Oxygen Model of Kidney Disease
k
Oxygen Model of Asthma
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Oxygen Model of Chronic Fatigue Syndrome
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Oxygen Model of Heart Fibromyalgia
k
Free
YouTube Course on Energy Events in Health and
Healing
k
Why Not Hydrogen for
Healing?
k
AA Oxidopathy -The Core Mechanism of Ischemic
Heart Disease
k
Improved Myocardial
Perfusion EDTA Infusions
k
Oxystatic Therapies
k
Respiratory-to-Fermentative
(RTF) Shift
k What Is Inflammation?
k Re-Thinking
the Immune System
k
Ali M. Cancer, Oxygen, nd
Pantotropha .
The dysox Model of
Aging
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The Dysox Model of Diabetes
and De-Diabetization
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Oxygen, Insulin Toxicity,
and Inflammation,
k
Castor Oil
Rubs for Colicky Babies and Children
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Infla-Oil Protocols for Arthritis
k
List of Oxygen Models of
Diseases
k
Oxygen Models
of Diseases
k
Chronic Disease Is Evolution in Reverse
k
Beginning of Life
k
List of Oxygen Models of
Diseases
k
Respiratory-to-Fermentative
(RTF) Shift in ATP
Production
k
Hydrogen peroxide
therapies: Recent Insights
into oxystatic and
antimicrobial actions.
k
Insulin Reduction and EDTA
Chelation
k
Dr. Ali’s Peroxide Foot Soaks Protocol
k
Dr. Ali’s
Hydrogen Peroxide-Salt Bath
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Hydrogen peroxide foot soaks with Meditation
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Intravenous hydrogen peroxide infusion
k
. Intravenous ozone infusion
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VThe Oxygen Model of
Cancer - Pyruvate Kinase Evidence
Related
Articles
* Origin of Life,
Origin of Disease
*
Oxygen-Driven Energetics: An Intelligent Design
*
Respiratory-to-Fermentative (RTF) Shift in ATP
Production
*
Fermentation: Good, Bad, and Ugly
*
Oxygen Models
of Diseases
*
Beginning of Life
*
Chronic Disease Is Evolution in Reverse
*
List of Oxygen Models of
Diseases
* Ali M.
Respiratory-to-Fermentative
(RTF) Shift in ATP
Production in Chronic Energy
Deficit States. Townsend
Letter for Doctors and
Patients. 2004. August/Sept.
issue. 64-65.
*
Ali M. Hydrogen peroxide
therapies: Recent Insights
into oxystatic and
antimicrobial actions.
Townsend Letter for Doctors
and Patients. 2004,
255;140-143.
*
What Does Chlorophyll Reveal About the Origin of
Life on the Planet Earth?
*
Ali M. Cancer, Oxygen, and pantotropha — Part I.
Townsend Letter for Doctors
and Patients.
2004;256:98-102.
Tutorial GG.11
Ali M. The dysox model of
aging.
Townsend Letter for Doctors
and
Patients.2005;269:130-134.
*
Tutorial GG.16
The Dysox Model of Diabetes
and De-Diabetization
Potential. Townsend
Letter-The examiner of
Alternative Medicine. 2007;
286:137-145.
* Tutorial GG.31 Ali M.
Oxygen, Insulin Toxicity,
Inflammation, And the
Clinical Benefits of
Chelation. Part I. Townsend
Letter-The examiner of
Alternative Medicine.
2009;315:105-109. October,
2009.
* Tutorial GG.32 Ali M.
Insulin Reduction and EDTA
Chelation: Two Potent and
Complementary Approaches For
Preventing and Reversing
Coronary Disease. Oxygen,
Insulin Toxicity,
Inflammation, and the
Clinical Benefits of
Chelation - Part II.
Townsend Letter-The examiner
*
Oxygen, Fermentation, and Disease -Commentary By
Natalie H.
*
Dr. Ali’s Peroxide Foot Soaks Protocol
* Dr. Ali’s
Hydrogen Peroxide-Salt Bath
1. Hydrogen peroxide foot soaks with Meditation
2. Intravenous hydrogen peroxide infusion
3. Intravenous ozone infusion
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