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Dr. Ali's Oxygen and Aging Course
Oxygen Governs the Aging Process
Majid
Ali, M.D.
Oxygen is the organizing
influence of human biology and governs the aging
process. From this simple idea I develop two other
dominant themes of this book. First,
dysfunctional oxygen metabolism (dysoxygenosis)
is the primary mechanism of cellular aging
and will be the single most important threat to the
human life span in the coming decades. Second, a
growing understanding of relationships among man's
internal and external environments will govern
all our plans for preserving health and
reversing disease.
Those simple ideas
form the core of my oxygen
theory of aging.1-4 But why
shouldn't the aging-genes be on the center stage?,
some readers might ask. Why not focus on
antioxidants?, some others might ask. Should not
those factors form the core of any theory of aging?
My view is that neither genes nor antioxidants can
work well in the presence of dysfunctional oxygen
metabolism. I marshal several lines of evidence to
support my view.
This book is not about low-fat
diets for living longer. The Japanese eat a very
low-fat diet and live longer than people in any
other country of the world. The Swiss have a very
high-fat diet and longer lifespan than any other
people except the Japanese. So much for the low-fat
and high-fat enthusiasts.
Neither is this book about taking
cholesterol-lowering drugs to extend life.
Cholesterol is an antioxidant. Coronary heart
disease is caused by oxidative injury. Blaming
healthy (unrancid, unoxidized) cholesterol for heart
disease is as silly as blaming water for illness.
Yes, excess rancid cholesterol threatens health just
as drinking polluted water does, but the problem is
rancidity of cholesterol as it is pollution in
water. Nearly all trials of cholesterol-lowering
drugs show a reduction in the rate of heart
attacks of less than one percent. That means more
than 990 of every 1,000 persons who take such drugs
get no benefits at all. It is important to point out
that all cholesterol-lowering drugs carry a
risk of causing cancer, liver disease, chronic
fatigue, and other problems. In 1997, for
professional readers, my colleague, Omar Ali, and I
discussed this subject at length in The Journal
of Integrative Medicine.1
The true story of drug therapies
for high blood pressure to prolong life is the same.
A large number of recent studies clearly show that
most people who were administered drugs for high
blood pressure for years did not benefit from those
therapies. There is broad consensus now that what
was considered "mild" hypertension does not increase
the risk of heart attacks, stroke, and kidney
disease. Even the staunchest supporters of the use
of drugs for mild hypertension now agree that
millions of persons have been needlessly given drugs
for decades. Indeed, over 95% of persons who are
diagnosed with the so-called mild hypertension
respond well to water therapy, meditation, optimal
choices in the kitchen, and gentle,
non-goal-oriented exercise.
Gene
Therapy Will Prolong ife Span Only When Oxygen
Homeostasis Is Preserved
In Oxygen and Aging (2000), I
predicted that gene therapies will not extend
human life span. For several years now, the gene
researchers have intoxicated with the promise of
extending life span and of miraculous cures with
gene therapies of diseases by the bundle. I have
believed for an equally long number of years that
gene therapy will have limited benefits for a very
small number of people with rare genetic disorders,
but only if the oxygen metabolism of those
persons can be preserved by natural supportive
therapies. The principal reason for my belief is
that the language of genes is far more
complex than, say, the English language with its
mere 26 letter-alphabet. There are an estimated
100,000 genes in the human genome and, in my view,
this is likely to prove to be a gross underestimate.
Beyond the simple matter of a 26- letter alphabet
versus 100,000 genes is the far more important issue
of genes reading and responding to their
microenvironment, something that letters in words
cannot do. Genes not only change their behavior in
response to environment, but also alter the behavior
of other genes. Of course, the environment also
changes the structure of genes. In this volume I
present my view that the oxygen order of human
biology profoundly affects the function of genes,
and we will succeed with gene therapies only to the
degree that we can preserve oxygen metabolism of the
recipient of such therapies. The claim of living
longer by taking out the faulty genes and replacing
them with new ones is pure Alice-in-Wonderland.
The drug industry seeks to extend human life span
with drugs in interesting ways. Read about a
fascinating story published in
the New York Times" at
Un-Aging With a
Drug.
The use of drug therapies, though
necessary for acute illness, is essentially blockade
medicine. All commonly used drugs block
essential cellular channels, receptors, enzymes,
pumps, and mediators of the healing response. It is
frivolous to think that the human lifespan can be
prolonged by blocking essential cell functions. It
is possible that some drugs may offer limited
benefits to some people, but only as long as
the fundamental oxygen order of human biology can be
preserved. One simple but telling argument for my
view is this: In the United States, more money is
spent on health care than in any other country in
the world and yet the life expectancy rate here is
among the lowest in developed countries.
Anti-aging
Industry
I am much amused by the
enthusiasm of the gurus of the anti-aging industry.
Some of them have declared aging to be a disease,
treatable with their favored products they sell.
When I listen to them or read what they write, I
wonder if they understand their stuff. I do
not. I have never seen a spoiled peach become
unspoiled, a rotten egg turn unrotten, or decomposed
grass become undecomposed. Nor have I seen any
anti-aging guru to "un-age" himself. I eagerly await
the time that some 60-year-old expert will become 45
years old. I continue to search for any
reasonable basis for their excitement. So far,
what I have seen is nothing but misleading claims
similar to those of merchants of
cholesterol-lowering drugs.
Anti-aging Hormones
Many anti-aging gurus are full of
ideas for prescriptions of anti-aging hormones. It
is evidently true that natural hormones are
essential for healthful aging. But
there is a big difference between studying changes
in the hormone levels as we advance in age and
claims of the ability of hormones to anti-age
people. Anti-aging gurus do not conduct any of their
own studies. They fondly cite studies conducted by
others with mice or medical students for weeks or
months. Their game is to sell their products by
promises of extended lifespan for decades, no matter
how irrelevant the studies they cite are to their
merchandise.
A
Scientist Has No Paradigm
A Scientist has but one
allegiance —to the truth in
his observations. We begin to grow when we
learn to observe. A theory may be proposed only to
explain observations. One must observe first.
I write this book to present my clinical and
experimental observations about the oxygen order of
human biology and how violation of that order leads
to dysfunctional oxygen metabolism. For the advanced
and professional readers, I published my
observations in a series of articles.2-14
My guidelines for healthful aging are based on those
observations made during the last four decades. The
oxygen theory of aging I propose in this book is my
attempt to shed some light on the mechanisms that
underlie my observations.
The
Dysox Model of Aging
In Spontaneity of Oxidation and
Aging (1983), I proposed The Oxidative Model of
Aging. In Oxygen and Aging (2000), I marshaled a
large body of evidence to support my model.
See
The dysox model of
aging
for a summary.
For additional reading on the
subject, I suggest my book Oxygen and Aging (2000),
available at
www.aliacademy.org
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*****
* Ali M.
Respiratory-to-Fermentative
(RTF) Shift in ATP
Production in Chronic Energy
Deficit States. Townsend
Letter for Doctors and
Patients. 2004. August/Sept.
issue. 64-65.
*
Ali M. Hydrogen peroxide
therapies: Recent Insights
into oxystatic and
antimicrobial actions.
Townsend Letter for Doctors
and Patients. 2004,
255;140-143.
*
What Does Chlorophyll Reveal About the Origin of
Life on the Planet Earth?
*
Ali M. Cancer, Oxygen, and pantotropha — Part I.
Townsend Letter for Doctors
and Patients.
2004;256:98-102.
Tutorial GG.11
Ali M. The dysox model of
aging.
Townsend Letter for Doctors
and
Patients.2005;269:130-134.
* Un-Aging With a
Drug?
Tutorial GG.11
Ali M. The dysox model of
aging.
Townsend Letter for Doctors
and
Patients.2005;269:130-134.
*
Tutorial GG.16
The Dysox Model of Diabetes
and De-Diabetization
Potential. Townsend
Letter-The examiner of
Alternative Medicine. 2007;
286:137-145.
*
Tutorial GG.31 Ali M.
Oxygen, Insulin Toxicity,
Inflammation, And the
Clinical Benefits of
Chelation. Part I. Townsend
Letter-The examiner of
Alternative Medicine.
2009;315:105-109. October,
2009.
* Tutorial GG.32 Ali M.
Insulin Reduction and EDTA
Chelation: Two Potent and
Complementary Approaches For
Preventing and Reversing
Coronary Disease. Oxygen,
Insulin Toxicity,
Inflammation, and the
Clinical Benefits of
Chelation - Part II.
Townsend Letter-The examiner
of Alternative Medicine.
2010;323:74-79. June 2010.
References
1. Ali M. Spontaneity of
Oxidation in Nature And Aging. Monograph. 1983.
Teaneck, New Jersey.
2. Ali M. Spontaneity of
Oxidation in Nature Is the true cause of Aging in
Humans and Root Cause of All Disease. page 199-304,
RDA: Rats, Drugs and Assumption. 1995. Life Span
Press, Denville, New Jersey.
3. Ali M. Lifespan Molecules. The
Cortical Monkey and Healing. page 18, 1990.
Institute of Preventive Medicine, Bloomfield, New
Jersey.
4.
Ali M, Ali O. AA
oxidopathy: the core pathogenetic mechanism of
ischemic heart disease. J Integrative Medicine
1997;1:1-112.
5. Ali M. Oxidative
coagulopathy in fibromyalgia and chronic fatigue
syndrome. Am J Clin Pathol 1999; 112:566-7.
6. Ali M. The basic equation of
life. The Butterfly and Life Span Nutrition. 1992.
The Institute of Preventive Medicine Press,
Denville, New Jersey, pp 225-236.
7. Ali M. Oxidative theory of
cell membrane and plasma damage. RDA: Rats, Drugs
and Assumptions. pp 281-302, 1995. Life Span,
Denville, New Jersey.
8. Ali M. Adrenergic
hypervigilence. What Do Lions Know About Stress? pp
137-172, 1996. Life Span Press, Denville, New
Jersey, .
9. Ali M. Oxidative regression to
primordial cellular ecology (ORPEC): evidence for
the hypothesis and its clinical significance. J
Integrative Medicine 1988;2:4-55.
10. Ali M. Amenorrhea,
oligomenorrhea, and polymenorrhea in CFS and
fibromyalgia are caused by oxidative menstrual
dysfunction. J Integrative Medicine 1998;3:101-124.
11. Ali, M. Oxidative menopausal
dysfunction (OMD-II): hormone replacement therapy (HRT)
or receptor restoration therapy (RRT)? J Integrative
Medicine 1998;3:125-139.
12. Ali M. Ali O. Fibromyalgia:
an oxidative-dysoxygenative disorder (ODD) J
Integrative Medicine 1999;1:17-37.
13 Ali M. Darwin, oxidosis,
dysoxygenosis, and integration. J Integrative
Medicine 1999;1:11-16.
14. Ali M. The oxidative-dysoxygenative
perspective of allergic disorders. J Integrative
Medicine 2000;4:15-24.
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