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Angry
Obesity Genes
—Why Are They Getting Angrier by the
Decade?
Majid Ali,
M.D.
On . May 26, 2011, The New York
Times told its readers that an estimated one in
three Americans are obese. It also announced that
"...genetics all play important roles." With these
seemingly journalistic words, the Times did its part
in confounding the real issues and added to the
massive and largely misleading obesity literature. I
read the article looking for any space given to
insulin toxicity or references to toxic
foods, toxic environments, and toxic thoughts. Not
unexpectedly, I found no such references.
Fat build-up in cells is the
result to cellular fermentation. At this level,
obesity is a fermentation problem. Since
fermentation in human cells occurs when there is
cellular oxygen dysfunction, at its root, obesity is
an oxygen problem. This, simply stated, is my Oxygen
Model of Obesity. Oxygen dysfunction is caused by toxicity
of foods, environment, and stress. In nearly all
cases, such toxicities lead to excess insulin in the
body which is fermenting, inflaming, and fattening.
The
prevailing calories-in-calories-out notion of weight
gain is misleading as it hides the truth of cellular
toxicity.
Three
Furies of Insulin Toxicity
Insulin in excess sets free its
three cellular furies:
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Excess Cellular Acidity
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Excess Cellular Free Radical Activity
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Excess Cellular Fluids Thickening
All three feed the fires of fermentation and fat
build-up.
The New York Times on
Obesity
Why do writers of The New York
Times focus on genes when they know there are
specific gene therapies for healthfull weight loss
and obesity reversal? The answer: They have no
opinions of their own. It is convenient for them to
call their "obesity experts," who themselves do not
practice clinical nutrition and so have nothing to
base their opinions on.
Focus on Genes Blames the Parents
and Dis-empowers the Individual
There are no gene therapies
available for treating obesity. By contrast, focus
on the issues of foods, environment, and toxic
thoughts empowers individuals and bring profound
health benefits while excess fat is removed.
Chemicalized foods, chronic
anger, fatigue that prevents exercise, and bad
science of nutrition — put them together and you
have a prescription for an obesity epidemic. Two
thirds of American are overweight at present. For
that tragedy, I hold responsible the gurus of weight
control industry who engage in frivolous debates
about low-carb, low-fat, and other dieting plans,
and ignore the real causes of obesity given above.
And the high priests of 'nutrition science' at the
American Medical Association, the National
Institutes of Health, The New England Journal of
Medicine, and Food and Nutrition Board? None of
them has the courage to speak out against those
chemicalize our foods, pollute our environment, or
victimize overweight individuals with toxic
information.
Misinformation about the science
of health, eating depleted and denatured foods, and
chemicalization of our cells — put them together and
you have a very effective prescription for causing a
massive epidemic of obesity. All those factors
eventually lead yo dysoxygenosis in adipocyte and
myocytes. That, simply stated, is the tragedy of
epidemics of obesity and diabetes that we witness
today. If we wish to understand the links between
obesity and many other disorders, again we need to
consider the basic scientific aspects of oxygen
homeostasis, cellular energetics and energy
homeostasis in the body.
In 2004, I introduced the Oxygen
Model of Obesity. Simply stated, this model explains
the origin and worsening of obesity to blocked
oxygen-driven cellular energetics. I pointed out
that excess body weight that cannot be lost by
ordinary efforts of reduced caloric intake and
increased physical activity is a cellular oxygen
deficiency state caused by impaired mitochondrial
function (the dys-ox state) in adipocytes and
myocytes.1 In that "adipomyocytic
dysoxygenosis (AD) model," the fundamental electron
transport enzymatic pathways that initiate metabolic
events and sustain a robust metabolism — and an
optimal weight — are injured by toxic foods, toxic
environment, toxic emotions, and toxic thinking. In
persistent obesity, adipocytes are increased in
number and distended with fat. More importantly, the
mitochondria are dysfunctional and the cells have
impaired oxygen utilization. That, simply stated, is
the root cause of the spreading epidemic of obesity
in the United States and elsewhere in the world. For
the general readership, I also published a second
article entitled "Oxygen Is Cellular Oxygen
Deficiency State," to provide a rational and
scientifically sound approach to achieving and
maintaining an individual's optimal weight.2
Three Furies of Obesity
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Excess Cellular Acidity
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Excess Cellular Free Radical Activity
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Excess Cellular Fermentation
Excess fat in the adipocyte is
oxidizing. Excess oxidation in the adipocyte impairs
cellular oxygen utilization. Adipocyte dysoxygenosis
so produced evokes"molecular inflammation" in the
cell. Molecular inflammation in adipose tissue
activates macrophages and vascular endothelial
cells, and so sets the stage for cellular
inflammation. Adipose inflammation so produced
further stokes the oxidative fires in adipocytes.
More fat, more oxidation, more oxygen dysfunction,
more inflammation — the cycle perpetuates itself,
increasing the degrees of oxidosis, acidosis, and
dysoxygenosis (the three furies of obesity). That,
simply stated, is the inflammatory theory of
obesity.
The Oxygen Model of Obesity
The adipomyocytic dysoxygenosis
model of obesity is distinct from the views of
obesity held by purists in the fields of clinical
bariatrics, energy homeostasis, and genomics on the
one side and the authors of weight control books,
who with uncommon exceptions are mere ghost writers
for the enormously rich weight control industry. The
adipomyocytic dysoxygenosis model of obesity — in my
view — is superior to other prevailing notions for
the following six principal reasons:
1. It holds the cellular
energetics and energy homeostasis in the
muscle and fat cells as its two
centerpieces, which simply cannot be
optimally maintained without daily physical
exercise.3
2. t focuses on the issue
of altered cellular metabolism as the primary phenomenon in the causation of
obesity, rather than on gene mutations
currently in fashion among academics.4-8
3. It makes a sharp
distinction between foods and ecologic
factors that preserve cellular oxygen
homeostasis and those elements that put it
in jeopardy, rather than engage in
meaningless low-carb/low-fat debates.9-17
4. It addresses the
critically important factors of food allergy
and related adverse food effects, as well as
large variations among individuals in their
requirements for nutrients. Those factors
are taken into account neither by promoters
of various weight loss diets nor by the
academics.18-22
5. It has a strong
explanatory power for molecular pathways
that link obesity to coronary heart disease,
cancer, and other disorders discussed in a
later section.
6. It provides sound
scientific basis of integrative plans to
effectively address the problem of obesity,
rather than the use of drugs like leptin,
dexfenfluramine (taken off the market) and
sibutramine (modulators of serotonin), and
others, none of which have proven safe and
effective in the long run.23-27
The real answer to the
devastating epidemics of obesity worldwide—the U.S
citizens suffer the most at present—is in a massive
and authetic education programs designed and
implemented by professionals who practice
nutritional medicine. I address this crucial issue
in the companion articles in my obesity series
listed below:
Dr. Ali's Seven for Weight
Loss
Below are the major aspects of my philosophy and
science of healthful weight loss:
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Be Aware Living
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Healing Kitchen Conversations
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Weight-wise Eating With Insulin-wise Meals
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Recipes for
Breakfast, Lunch, Dinner, and Snacks
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Optimal Vitamin and Mineral Supplementation
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Spices and Herbs for Blood and Liver Detox
k Limbic
Exercise
Related Articles
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Oxygen
Model of Obesity
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Insulin Is the Fattening Hormone
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Angry
Obesity Genes
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DR. Ali's Weight Loss
Guidelines
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The Insulin-Obesity-Diabetes
Continuum
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Diabetes Pandemic
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Dr. Ali's Diabetes Reversal program
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Insulin-Wise-Eating
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Insulin-Wise Foods, Insulin-Saving Recipes
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Dr. Ali's Insulin-Smart Recipes
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The Oxyegn Model of Diabetes
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The Oxygen
Model of Obesity
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Master List of Dr.
Ali's Recipes
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Dr. Ali's
Line of Omelettes for Weight Loss and Diabetes
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Dr. Ali's Breakfast 3-4 Days a
Week
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Dr. Ali's Dinner Recipes
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Dr. Ali's
Insulin-Wise Breakfast
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Dr. Ali's Insulin-Wise Lunch
Recipes
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Dr. Ali's Breakfast 3-4 Days a
Week
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Dr. Ali’s Flax and
Chia Seeds Omelete
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Dr. Ali's
Ginger - Walnut Omelette
k Dr. Ali's Edamame
Omelette
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Dr. Ali's Sesame
Omelette
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Dr. Ali's Garlic
Omelette
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Dr. Ali's Onion
Omelette
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Dr. Ali's
Insulin-Wise Pink Dal (Lentil) Lunch Recipe
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Dr.
Ali's Black dal (lentil) Lunch Recipe
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Dr. Ali’s
Insulin-Wise Flax and Chia Seeds Omelette
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Dr. Ali’s Insulin-Wise Tuna-Tiki Recipe
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Dr. Ali's Insulin-Smart Palak-Tiki Recipe
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Dr. Ali's Vege-Tiki Recipe
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Insulin-Wise Foods, Insulin-Saving Recipes
k Dr. Ali's Insulin-Wise
Breakfast - Personalized
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Insulin-saving Almond snack
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Dr. Ali's
Insulin-Wise Pink Dal (Lentil) Lunch Recipe
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Dr.
Ali's Black dal (lentil) Lunch Recipe
k Foods
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Recipe
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Insulin-Wise Foods,
Insulin-Saving Recipes
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Insulin-Wise Foods, Insulin-Saving Recipes
k Dr. Ali's Insulin-Wise
Breakfast - Personalized
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Insulin-saving Almond snack
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Nutrition for
Health and Healthful Aging
k Stress - Physiology
and Pathology
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Be Your Own Healer
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The Insulin-Obesity-Diabetes
Continuum
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Diabetes Pandemic
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Diabetes - Now You See It, Now You Don't
*I nsulin
Evolutionary
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Seven Stages of
Insulin Toxicity
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Prediabetes
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Subtypes of
Diabetes Type 2
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Less Insulin, More Life
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Insulin-Wise-Eating
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Dr. Ali's Insulin-Smart Recipes
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Dr. Ali's
Insulin-Wise Breakfast
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Dr. Ali's Insulin-Wise Lunch
Recipes
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How Blood Cells Tell the Diabetes
Story?
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Insulin Toxicity
Tutorial J.1 The
Obesity Epidemic and the
Academicians
Tutorial J.2. The
Obesity Epidemic and the
Ghostwriters of the Weight Loss
Industry
Tutorial J.3 How
Do People Become Obese?
Tutorial J.4 What Does An
Intelligent Fat Cell Teach Us?
Tutorial J.5 What Is the
Inflammation-Aging Obesity Connection?
Tutorial J.6 The Grease and
Detergent Model of Obesity
Tutorial J.7 How
Does Obesity Cause Premature Aging
and Early Death?
Tutorial J.8 Is
Persistent Obesity a Cellular
Toxicity problem?
Tutorial J.9. The
Travesty of Food Pyramids
Tutorial J.10. Is
Low-Fat Weight Loss Programs
Fattening?
Tutorial J.11. Is
Low-Carb Weight Loss Programs
Fattening?
Tutorial J.12
What Are Energy Homeostasis and
Adaptive Thermogenesis?
Tutorial J.13
What Is the Inflammatory Theory of
Obesity?
Tutorial J.15
What Is the Oxygen Model of Obesity?
Tutorial J.16.
The Oxygen Model of Obesity Explains
Its Link to Heart Disease, Diabetes,
Cancer, and Other Disorders
Tutorial J.17.
What is Optimal Weight for the Life
Span?
Tutorial J.18 How
Can Fat-Burning Enzymes be
Upregulated?
Tutorial J.19.
How Does Limbic Exercise Prevent
Obesity?
Tutorial J.20
Obesity Genomics
Tutorial J.21
What Is the Obesity-Heart Attacks
Connection?
Tutorial J.22
What Is the Obesity-Memory
Connection?
Tutorial J.23
What Is the Obesity-Cancer
Connection
Tutorial J.24. The Spreading Epidemic of
Mitochondrial Dysfunction
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